There may be no restriction on our ability to learn the general principles and symmetries upon which the cosmos operates. And this is what is really interesting!
On the other hand, deterministic chaos and quantum mechanics have taught us that any exact and detailed predictions on how the future unfolds (on any time or spatial scale) are impossible. If the initial conditions cannot be known perfectly, for example, no accurate predictions can be made. You can get acceptable models for the weather on a one week time frame, but the models fail fairly fast beyond that.
This is something we need to process, accept, and stop wasting time/effort on hopelessly idealistic work-arounds.