We cannot retrodict the mass of the electron. We cannot identify the dark matter. We do not understand dark energy. The standard model of particle physics has at least 7 serious problems that remind us that it can only be a provisional model.
If there ever was a more propitious time to seriously question our fundamental assumptions, I cannot remember it. Are we sure strict reductionism is the only game in town? Are we sure of our assumption that scale is absolute? Are we so sure that fractal paradigms are not worth exploring? Have we fully appreciated the self-evident fact that the observable cosmos has a highly stratified hierarchical organization and is rife with self-similarity? Are we too quick to come up with rationalizations for summarily dismissing alternative paradigms?